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THE EFFECTS OF ODONTOGENIC AND NONODONTOGENIC TISSUES ON BONE HEALING IN GUINEA PIG MANDIBLE

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Abstract

ÃÖ±Ù Ä¡°úÀÓ»ó¿¡¼­´Â ¹ßÄ¡³ª ¿Ü»ó¿¡ ÀÇÇÑ °ñ ¼Õ»ó ÀÌ¿Ü¿¡µµ ¾Ç¾È¸é¼ºÇüÀ̳ª ÀΰøÄ¡¾Æ¸Å½Ä
À» ½ÃÇàÇϱâ À§ÇÑ ÀÎÀ§ÀûÀÎ °ñ¼Õ»óÀÌ Á¡Â÷ Áõ°¡µÊ¿¡ µû¶ó, ¼Õ»ó°ñÀ» ¼º¼÷µÈ ±¸Á¶·Î ºü¸£°Ô
Àç»ý½ÃÅ°´Â °ÍÀÌ Ä¡°úÀÇ»çµéÀÇ Ä¿´Ù¶õ °ü½É»ç°¡ µÇ°íÀÖ´Ù.
ÀÌ¿¡ ÀúÀÚµéÀº ¹ßÄ¡¿Í°¡ Ä¡À¯µÇ´Â °úÁ¤¿¡¼­ Ä¡¼º Á¶Á÷°ú ¿¬°üµÇ¾î Ä¡À¯µÇ´Â °ñÁ¶Á÷ÀÇ À¯
Çü°ú ºñÄ¡¼ºÁ¶Á÷ÀÎ ¾Ç°ñÁ¶Á÷À¸·ÎºÎÅÍ À¯·¡µÇ¾î Ä¡À¯µÇ´Â °ñÁ¶Á÷ÀÇ À¯ÇüÀ» ¼­·Î ºñ±³Çϱâ À§
ÇÏ¿©, guinea pigÀÇ Ä¡Á¶°ñ¿¡ ÀÎÀ§ÀûÀ¸·Î Ä¡°ú¿ë ¹Ù¸¦ »ç¿ëÇÏ¿© ¼Õ»óÀ» °¡ÇÑ ÈÄ, °¢°¢ÀÇ Á¶
Á÷À¸·ÎºÎÅÍÀÇ ¼Õ»ó°ñÀÇ Ä¡À¯¾ç»óÀ» °üÂûÇÏ¿© ¹ßÂ÷¿ÍÀÇ Ä¡À¯°úÁ¤À» ±¸¸íÇÏ°íÀÚ ÇÏ¿´À¸¸ç, Çâ
ÈÄ ÀÓ»óÀûÀ¸·Îµµ ¼º°øÀûÀÎ ¹ßÄ¡¿ÍÀÇ Ä¡À¯¸¦ À¯µµÇÒ ¼ö ÀÖ´Â ¸íÈ®ÇÑ ±âÁØÀ» Á¦½Ã ÇÏ°íÀÚ º»
¿¬±¸¸¦ ½ÃÇàÇÏ¿´´ø ¹Ù, ´ÙÀ½°ú °°Àº °á°ú¸¦ ¾ò¾ú´Ù.
1.¼Õ»ó°ñ¿Í´Â Ä¡¼º Á¶Á÷À¸·ÎºÎÅÍ ±â½ÃµÈ °ñÁ¶Á÷¿¡ ÀÇÇÏ¿© Ãʱ⿡ ºü¸£°Ô Ä¡À¯µÇ¾ú´Ù.
2. ±âÁ¸°ñÃø¿¡¼­ ±â½ÃµÈ °ñÁ¶Á÷Àº °ñ±âÁúÀÌ ±ÔÄ¢ÀûÀ̾úÀ¸³ª, Ä¡¼º °ñÁ¶Á÷À¸·ÎºÎÅÍ ±â½ÃµÈ
°ñÁ¶Á÷ÀÇ °ñ±âÁúÀº ºÒ±ÔÄ¢ÇÏ¿´´Ù.
3. Ä¡¹ÐÇØÁø Ä¡¼º °ñÁ¶Á÷ÀÇ ³»ºÎ¿¡¼­´Â ½ÇÇè 3ÁÖ ÈÄ¿¡ Èí¼ö°¡ ÀϾ±â ½ÃÀÛÇÏ¿© Á¤»ó°ñ
Á¶Á÷ÀÇ À¯ÇüÀ¸·Î Á¡Â÷ º¯ÇüµÇ¾ú´Ù.
#ÃÊ·Ï#
This study was for comparing healing patterns and effects between with odontogenic
and nonodontogenic tissues on the defected mandible. Experimental bone defects that
measured 3 §® in diameter were created on the mandibular body of guinea pig by
removal of bone with the use of trephine burs and bone defects were grafted with
Biogran(Orthovita Co., U.S.A.) and covered with Dura Mata(Pfrimmer-Viggo GmbH Co.,
Germany). Guinea pigs were serially terminated by fours on the 3 days, the 1 week, the
2 weeks, the 3 weeks, the 4 weeks, and the 5 weeks after experiment, and the
mandibular body was removed and fixed with 10% neutral formalin. They were
decalcified adn embedded in paraffin as using the usual methods. The specimen
sectioned and stained with hematoxylin and eosin and toluidine blue. They were
observed with a light microscope and a polarizing microscope.
The obtained results were as follows :
1. Defected bone was healed fast from the odontogenic tissues in early stage of the
experiment.
2. The arrangement of the bone matrix was relatively regular in the bone from the
nonodontogenic tissues, but irregular in the bone from the odontogenic tissues.
3. Compact bone has started to be resorbed and changed to the pattern of matrix
bone tissue from 3 weeks after experiment.

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